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. 2022 Jan 10;12:1. doi: 10.1038/s41398-021-01683-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Induction of LTD by using SLFS in WT mice, resulted in a stable depression that was statistically significant throughout the recorded time period of 180 min (P = > 0.05, n = 7). B SLFS was delivered to Exon 33^−/− mice which resulted in a potentiation after 30 min and was stable for 180 min (n = 7). Dotted graph represents A for comparison. A significant difference was found between WT and Exon 33^−/− mice from 25 min (Utest, 25 min, P = 0.004; 60 min, P = 0.001; 120 min, P = 0.001; 180 min, P = 0.001). C Induction of E-LTD using WLFS in WT mice showed a depression that was short lasting (85 min, P = 0.03, n = 8) which then returned to baseline levels. D Application of WLFS did not show any significant depression throughout the recording time period of 180 min in Exon 33^-/- mice (P = < 0.05, n = 7). Dotted graph represents C for comparison. The bar graphs represents the comparison of potentiation/depression at 60 min time points between WT and to Exon 33^−/− mice. Single arrow represents the time point of application of SLFS and WLFS. SLFS- strong low frequency stimulation, WLFS- weak low frequency stimulation. Analog traces and scale bars as in Fig. 1. Error bars in all graphs indicate ±SEM.