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. 2022 Jan 10;12:412. doi: 10.1038/s41598-021-04454-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship and functional analysis of differentially expressed mRNAs. (a) Venn diagram of genes differentially expressed in Normal/Model, Model/MSCs and Normal/MSCs groups. (b) KEGG pathway analysis³⁶ of Normal/Model and Model/MSCs groups measured by mRNA microarray chip. (c) qRT-PCR verification of differentially expressed genes in ECM-receptor interaction signal pathway (These genes were obtained from MAP04512 and MAP04510 of KEGG: https://www.kegg.jp/kegg/). *p < 0.05, **p < 0.01.