Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 10;13(1):31. doi: 10.1038/s41419-021-04480-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — A mRNA and B protein expression levels of PGC-1α were decreased in adenine-fed mice. C mRNA expression of mitochondrial dynamic-related genes including Mfn, Tfam, and Drp1were altered in adenine-fed mice. D mRNA and E protein expression levels of the NLRP3 inflammasome pathway were increased in adenine-fed mice. F Concentrations of IL-1β and IL-18 assessed by ELISA were increased in adenine-fed mice. G mRNA and H protein expression levels of fibrotic markers including fibronectin and collagen 1, and apoptotic cell death markers of Bax/bcl-2 and cleaved caspase-3 were increased in adenine-fed mice. Note: *P < 0.05 vs. control. PGC-1α peroxisomal proliferator-γ coactivator-1α; NLRP3 NOD-like receptor family, pyrin domain-containing 3; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; ELISA enzyme-linked immunosorbent assay; Ade adenine.