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. 2022 Jan 10;13(1):38. doi: 10.1038/s41419-021-04484-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Morphological changes (left panel) and quantitative analysis of LVEF and FS (right panel) in rat hearts were detected by echocardiography, **P < 0.01, ***P < 0.001. B Serum expression of myocardial enzymes CKMB, LDH and AST were quantified in rats of respective groups, *P < 0.05, **P < 0.01, ***P < 0.001. C A representative section of the left ventricle from respective groups of rats showing sporadic mitochondrial, damaged disconnected myofibers, and thinner myofibers. D IHC analysis was performed to detect the expression of NLRP3 and GSDMD-N in hearts of DCM rat after treated with MCC950. E Masson staining was done in heart tissues of DCM rats treated with MCC950.