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. 2022 Jan 10;12:460. doi: 10.1038/s41598-021-04243-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional characterization of the TT linkers. (A) Structural superposition of the A-form complex with the EF dimer of the B-form complex, which is colored in yellow, blue, and red. The A-form complex is colored as in Fig. 1A. (B) Dimerization mediated by the TT linkers of the A-form structure. (C) Dimerization mediated by the TT linkers of the EF dimer of the B-form structure. (D) Stacking with the pseudo T-tetrad and tilting of the G-tetrad 1. (E) CD spectra analysis of the native and TT linker mutated TBAs. Except the mutations listed in the figure, the sequences of the mutants are identical to that of TBA.TBA (native or mutant) and Pb²⁺ concentrations are 10 μM and 50 μM, respectively. Structural figures were displayed using PyMOL (http://www.pymol.org/).