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. 2022 Jan 10;13:25. doi: 10.1038/s41467-021-27631-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overlap between drug classes in the dataset (A), between drug substances in the antipsychotic group (B) and salicylate group (C), between subclasses in immunotherapy (D) and cytotoxic (E), and types of vaccines in the vaccine group (F). DTPP diphteria, tetanus, pertussis, and/or polio vaccine, HepA/HepB hepatitis A and/or hepatitis B vaccine. Subclasses in immunotherapy regroup anti-PD1 (cemiplimab, nivolumab, and pembrolizumab), anti-PDL1 (atezolizumab, avelumab, and durvalumab), anti-CTLA4 (ipilimumab), and interleukin-2 (aldesleukin). Subclasses in cytotoxic regroup alkylating agents (busulfan and cyclophosphamide), anthracyclines (daunorubicin, doxorubicin, epirubicin, and idarubicin), and antimetabolites (cytarabine and fluorouracil). Due to graphical limitations, some overlaps cannot be displayed. Exact combinations are presented with UpSetR plots in the Supplementary Information file.