Table 2.

Associations of genetically predicted metabolic and lifestyle factors with senile cataract risk in sensitivity analyses.

Source	Exposure	SNPs	Cochrane’ Q	pintercept	Weighted median			MR-Egger			Contamination mixture
					OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
FinnGen	Body mass index	305	362	0.102	1.11	0.94, 1.31	0.200	0.99	0.77, 1.27	0.928	1.13	1.01, 1.28	0.049
FinnGen	Type 2 diabetes	472	552	0.652	1.08	1.01, 1.15	0.015	1.09	1.01, 1.17	0.025	1.06	1.02, 1.09	0.010
FinnGen	Systolic blood pressure	217	217	0.105	1.08	0.93, 1.24	0.314	0.82	0.56, 1.18	0.278	1.14	0.99, 1.3	0.078
FinnGen	Coffee consumption	12	12	0.444	1.33	1.01, 1.75	0.040	1.57	1.05, 2.34	0.051	1.31	1.02, 1.68	0.045
FinnGen	Alcohol consumption	80	104	0.279	0.86	0.55, 1.35	0.507	0.60	0.27, 1.33	0.213	0.64	0.4, 1.11	0.130
FinnGen	Smoking initiation	297	418	0.460	1.18	1.03, 1.36	0.018	1.00	0.65, 1.55	0.987	1.20	1.08, 1.34	0.003
UKBB	Body mass index	312	318	0.444	1.14	0.91, 1.44	0.243	1.04	0.75, 1.44	0.806	1.13	0.94, 1.32	0.216
UKBB	Type 2 diabetes	492	643	0.835	0.99	0.91, 1.08	0.814	1.01	0.91, 1.13	0.788	1.00	0.96, 1.05	0.999
UKBB	Systolic blood pressure	224	266	0.954	1.24	1.02, 1.53	0.035	1.19	0.68, 2.11	0.540	1.43	1.13, 1.92	0.004
UKBB	Coffee consumption	12	14	0.439	0.85	0.57, 1.28	0.441	1.06	0.59, 1.91	0.842	0.65	0.47, 1.13	0.191
UKBB	Alcohol consumption	84	117	0.219	1.05	0.55, 2.00	0.892	0.76	0.34, 1.71	0.513	1.52	0.9, 4.44	0.130
UKBB	Smoking initiation	312	385	0.544	1.13	0.95, 1.35	0.162	1.42	0.82, 2.46	0.211	1.27	1.03, 1.49	0.028

CI confidence interval, OR odds ratio, SNPs single nucleotide polymorphisms, UKBB UK Biobank.