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. 2022 Jan 10;13:55. doi: 10.1038/s41467-021-27571-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Visualization of UMAP plot displaying 26 clusters segregated from all 31,260 nuclei isolated from adult control and CUS mouse cortices (n = 8 mice). Ex, excitatory neurons; Inh, inhibitory neurons; Astro, astrocytes; OPC, oligodendrocyte precursor cells; Oligo, oligodendrocytes; MG, microglia; EC, endothelial cells. b Bubble chart showing expression of cell type-specific marker genes for each cortical cell cluster. c UMAP plots depicting clusters identified from control (15,911 nuclei) and CUS nuclei (15,349 nuclei). d Percentage of control and CUS nuclei for every cortical cluster (n = 4 each group). e Volcano plots of differentially expressed genes between control and CUS cortical nuclei (FDR < 0.2). Upregulated genes are shown in red, downregulated genes are displayed in blue, and insignificant genes are shown in gray. Error bars represent s.e.m.