Table 2.

Summary of proposed binding modes in both 40 mM SDS and water solution for investigated amylin analogues at pH = 10.

Ligand	40 mM SDS	H2O16,34
Rat amylin	NH2, 2N−	Nim 3N−
Amylin1–19	Nim, 3N−	Nim, 3N−
Pramlintide	Nim, 3N− or NH2, 3N−	Nim, 3N− or NH2, 3N−
Ac-pramlintide	Nim, 3N−	–