Fig. 1. Cohorts definition, study design, and major skin cell types revealed by clustering of scRNA-seq data.

a Schematic diagram for the cohorts definition and study design. The number of cases and controls for the discovery cohort and each validation cohort were indicated. b UMAP visualization of skin scRNA-seq profile of the discovery cohort, discriminative marker genes for each cell type was indicated in parentheses. c Dot plot of the top marker genes for the identification of major skin cell types. d UMAP plot for skin cells split by patients and HC.