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. 2022 Jan 11;8:2. doi: 10.1038/s41421-021-00353-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a UMAP visualization of the sub-clustering of skin DC/Mac cells of the discovery cohort. b Dot plot of the top marker genes for the identification of subsets in the skin DC/Mac cluster. c Module scores of each macrophage subset calculated using the top ten signature genes of each cluster (genes in Supplementary Fig. S2d). P value was calculated using a two-sided unpaired Student’s t-test. d Donor composition for each cluster obtained in the sub-clustering of skin DC/Mac cells. e UMAP plot for skin DC/Mac cells split by patients and HC. f UMAP visualization of the sub-clustering of skin T/NK cells of the discovery cohort. g UMAP plot of the top marker genes for the identification of subsets in the skin T/NK cluster. h Donor composition for each cluster obtained in the sub-clustering of skin T/NK cells. i UMAP plot for skin T/NK cells split by patients and HC.