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. 2022 Jan 11;8:2. doi: 10.1038/s41421-021-00353-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expressions of TIGIT, LAG3, HAVCR2, PDCD1, and CTLA4 in skin CD4⁺ and CD8⁺ T cells of the discovery cohort. b Expressions of TIGIT and LAG3 in the skin CD8⁺ T cells of each sample. c Expressions of TIGIT and LAG3 in the skin by cases and controls of validation cohort 1 as determined by bRNA-seq. d Co-localization of TIGIT and CD8 in L-LEP lesions. The nucleus was stained by DAPI. e Co-localization of LAG3 and CD8 in L-LEP lesions. The nucleus was stained by DAPI.