Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 10;10:5. doi: 10.1038/s41413-021-00179-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — Kindlin-2 deletion accelerates progression of coccygeal IVDD in the presence of abnormal mechanical stress in mice. a Overview of the experimental design of coccygeal IVDs needle stab (CINS) model. b, c SO&FG staining and histological scores of coccygeal IVDs in control and cKO mice with or without CINS. Scale bar, 100 μm. n = 6. d, e Changes in the disc height index (%DHI) (Co6-7, 7–8) were evaluated by micro-computed tomography (μCT) analyses. n = 6. f–h IF staining of Col2a1 and Mmp13 in NP tissues in coccygeal IVDs of control and cKO mice with or without CINS. Scale bar, 50 μm. n = 6. i, j TUNEL staining of NP tissues in coccygeal IVDs of control and cKO mice with or without CINS. Scale bar, 50 μm. n = 6. **P < 0.01, ***P < 0.001