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. 2022 Jan 10;7:1. doi: 10.1038/s41541-021-00424-2

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© The Author(s) 2022, corrected publication 2023

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Fig. 1 — a Design of experimental protocol in hα-Syn Tg D line mice vaccinated with various MultiTEP-based DNA immunogens targeting different epitopes of hα-Syn. Mice were 2.5–4.5 mo of age at the start and 12–14 months old at the end of the experiment. b Endpoint titers of antibodies specific to hα-Syn85–99, hα-Syn109–126, and hα-Syn126–140 peptides were detected in sera collected after the fourth immunization with indicated immunogens by ELISA. Error bars indicate the mean values of antibody titers ± SEM (*p < 0.05). PV-1950D induced higher responses to epitopes aa109–126 (p < 0.05 for female and male mice) and aa126–140 (p < 0.01 for female mice and p < 0.05 for male mice) compared with the epitope aa85–99. c Antibody titers of antibodies specific to recombinant full-length α-Syn. Titers were significantly higher in PV-1947D vs. PV-1948D (p < 0.05) in female and PV-1949D vs. PV-1948D (p < 0.01) male mice groups. Error bars indicate the mean values of antibody titers ± SEM.