Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 10;7:1. doi: 10.1038/s41541-021-00424-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Representative images of brain sections from male mice pretreated with proteinase K (PK) and immunostained with an antibody against α-synuclein. Each panel illustrates from top to bottom an overview of the brain, neocortex, hippocampus, striatum, and substantia nigra regions in non-Tg, and hαSyn Tg mice treated with vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. b Image analysis of PK-resistant αSyn in the neuropil expressed and corrected optical density in the neocortex, hippocampus, striatum, and substantia nigra (from left to right) in male mice. c Image analysis of PK-resistant αSyn-positive cell counts per 0.1 mm² in the neocortex, hippocampus, striatum, and substantia nigra (from left to right) of male mice. d Representative images of brain sections from female mice pretreated with PK and immunostained with an antibody against α-synuclein. Each panel illustrates from top to bottom an overview of the brain, neocortex, hippocampus, striatum, and substantia nigra regions in non-Tg, and αSyn Tg mouse treated with vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. e Image analysis of PK-resistant αSyn in the neuropil expressed as optical density in the neocortex, hippocampus, striatum, and substantia nigra (from left to right) in female mice. f Image analysis of αSyn cell counts per 0.1 mm² in the neocortex, hippocampus, striatum, and substantia nigra (from left to right) in female mice. The scale bar in the overview is 250 µm, the others are 25 µm. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.