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. 2022 Jan 10;7:1. doi: 10.1038/s41541-021-00424-2

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© The Author(s) 2022, corrected publication 2023

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Fig. 6 — a Representative images of brain sections from male mice immunostained with an antibody against the dopamine cell marker tyrosine hydroxylase (TH). From top to bottom, each panel illustrates the striatum and substantia nigra regions in non-Tg, and αSyn Tg mouse with the vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. b Image analysis of TH-positive fibers expressed as corrected optical density in the striatum and total TH-positive cell counts per midbrain in substantia nigra of male mice. c Representative images of brain sections of female mice of immunostained with an antibody against TH. Each panel illustrates from top to bottom the striatum and substantia nigra in non-Tg, and αSyn Tg mouse with a vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. d Image analysis of TH-positive fibers expressed as corrected optical density in striatum and total TH-positive cell counts per midbrain in substantia nigra of female mice. The scale bar is 100 µm for Striatum and 10 µm for S. Nigra. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.