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. 2022 Jan 10;7:1. doi: 10.1038/s41541-021-00424-2

Fig. 8. Vaccination with MultiTEP-based DNA vaccines significantly reduced microgliosis in α-synuclein transgenic mice.

Fig. 8

a Representative images of the brain sections from male mice immunostained with an antibody against the microglial cell marker -Iba1. Each panel from top to bottom represents an overview of the brain, neocortex, hippocampus, striatum, and substantia nigra regions in non-Tg, and αSyn Tg mice with a vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. b Image analysis of Iba1 positive cell count per 102 in the neocortex, hippocampus, striatum, and substantia nigra of male mice. c Representative images of the brain sections of female mice immunostained with an antibody against the microglial cell marker Iba1. Each panel illustrates from top to bottom an overview of the brain, neocortex, hippocampus, striatum, and substantia nigra regions in non-Tg, and αSyn Tg mice with a vehicle, PV-1947D, PV-1948D, PV-1949D, and PV-1950D vaccination. d Image analysis of Iba1 positive cell counts in the neocortex, hippocampus, striatum, and substantia nigra of female mice. The scale bar in the overview is 250 µm, the others are 25 µm. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.