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. 2022 Jan 10;12:381. doi: 10.1038/s41598-021-03787-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of epithelial GPR120 correlates with CRC development (a) The expression levels of FFAR4 gene were quantified by qRT-PCR in healthy colon (n = 9), adenomas (n = 9) and adenocarcinoma (n = 17) from human samples. (b) Representative immunostaining for GPR120 in human samples of Normal mucosa (n = 6), High-Grade Adenomas (HGA) (n = 6), T1 (n = 6) and T2 (n = 6) tumors, (c) and relative quantification of positive area. Values are expressed as median percentage of positive over total area ± 95% CI. Magnification: 20X. Scale bar: 50 μm. (d) Gene expression of FFAR4 in the indicated tissues annotated in the GENT2 database, expressed as Log2 and plotted according to tissue type. Values are expressed as median (horizontal line) ± IQR (interquartile range, boxes), dots represent outliers. Green box highlights FFAR4 expression in CRC (n = 4047) and healthy (n = 398) colon tissue. *p value < 0.05; **p.value < 0.001 by Mann Whitney test (a-c) and Student t test (d).