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. 2022 Jan 10;13:114. doi: 10.1038/s41467-021-27684-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot analysis of Acp5a (p = 0.0029) and Acp5b (p = 0.0003) expression in primary mice lung fibroblasts (PMLFs) following TGF-β1 induction. b Western blot analysis of ACP5a (p = 0.0040) and ACP5b (p = 0.0455) expression in primary human lung fibroblasts (PHLFs) following TGF-β1 induction. c Representative results for coimmunostaining of Acp5 and p-Smad3 in PMLFs. The nuclei were stained blue by DAPI, and the images were taken under original magnification ×400. d–e Western blot analysis of Fibronectin (d: p = 0.0096, e: p = 0.0295), Col1a1 (d: p = 0.0003, e: p < 0.0001), α-SMA (d: p < 0.0001, e: p < 0.0001), Acp5a (d: p < 0.0001, e: p < 0.0001) and Acp5b (d: p = 0.02, e: p < 0.0001) expression in PMLFs following SB431542 (d) and SIS3-HCL (e) treatment. The data are represented as the mean ± SEM of three independent experiments and two-side Student’s t-test was administered to analyze the statistical significance of differences between two groups. *p < 0.05; **p < 0.01; ***p < 0.001. Source data are provided as a Source Data file.