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. 2022 Jan 10;13:159. doi: 10.1038/s41467-021-27572-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a A schematic diagram of the workflow for investigation of human brain lysine succinylome by label-free quantitation (See methods section). b After quantitative data screening and mining, the combined results from 20 brain samples in two batches revealed 932 common succinylated peptides quantified from 259 proteins (Supplementary Data 4). c A schematic diagram of the workflow for quantitative proteomics of human brain by Tandem mass tags (TMT) labeling analysis (See methods section). d After quantitative data screening and mining, the combined results from 20 brain samples in two batches revealed 4442 common proteins in both AD and controls (Supplementary Data 5). Eighty-one proteins showed significant alterations between samples patients with AD and controls. e The overlap between succinylomes and proteomes. Nearly all of the succinylated proteins were also identified in its global proteomic analysis. Source data are provided as a Source Data file.