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. 2022 Jan 10;13:59. doi: 10.1038/s41467-021-27686-7

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© The Author(s) 2022

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Fig. 2 — a Open conformation of CsTOP1 solved by crystallography. b Sequence alignment between CsTOP1 and HsTOP1. The position of the lips are indicated with dotted lines. The residues interacting with DNA are shown with arrows. The coloring scheme is the same as in Fig. 1, apart from the Hinge loop which is shown in orange.