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. 2022 Jan 10;13:59. doi: 10.1038/s41467-021-27686-7

Fig. 8. Proposed model of DNA entry inside the TOP1 catalytic site.

Fig. 8

a In its apo-state, the CAP domain (green) and the CAT, Linker, C-ter domains (pink) can rotate. Lip2 is interacting with the DNA-binding region of the catalytic module. b After the displacement of the Lip2, one DNA molecule can enter the TOP1 catalytic site. c The Capping module rotates to trap DNA in the catalytic site. This rotation relies on the hinge and one conserved tyrosine from the CAP domain. The interaction between the two lips stabilizes the closed conformation.