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. 2022 Jan 10;12:452. doi: 10.1038/s41598-021-04098-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CCR2 facilitates the accumulation of round macrophages within the colon submucosa of IL10RA-deficient mice. (A) Immunofluorescent images from the proximal colon of representative mice of the indicated genotypes showing the localization and morphology of cells staining with Iba1. 20 × magnification, Scale bar indicates 100 μm. The images from IL10RAKO and DKO mice demonstrated a similar density of ramified Iba1-positive cells in the lamina propria (LP) but a reduction in round Iba1-positive cells within the submucosa (SM, filled arrows) of DKO mice compared to IL10RAKO mice. (B) Numbers of Iba1-positive cells in 5 fields from the colon of WT (n = 4), CCR2KO (n = 6), IL10RAKO (n = 12) and DKO (n = 15) mice, as indicated.