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. 2022 Jan 10;12:452. doi: 10.1038/s41598-021-04098-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The absence of CCR2 does not change the gene expression signature of IL10RA-deficient intestinal macrophages. (A) Principal component analysis comparing the gene expression profiles of MHCII⁺Ly6C⁻ colonic macrophages isolated from WT (Cdcs1^+/+), IL10RAKO (Cdcs1^+/+Il10ra^−/−), and DKO (Cdcs1^+/+Il10ra^−/−Ccr2^−/−) mice determined by RNAseq. (B) Heat map demonstrating differences in gene expression between groups, including the 4 genes that were expressed at significantly different levels between macrophages isolated from IL10RAKO (KO) and DKO mice, as well as an additional 46 genes that with the lowest adjusted P values between WT and IL10RAKO macrophages. (C) Expression of selected genes as indicated. WT (n = 4), IL10RAKO (n = 4) and DKO (n = 4) mice. Log CPM = Log2 counts per million reads.