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. 2022 Jan 10;12:427. doi: 10.1038/s41598-021-04137-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Venn diagram of genes and proteins regulated by IFN types. The Venn diagram shows the number of genes or proteins regulated by one or more IFN type (Type I, II or III). Venn diagrams were generated based on the upregulated genes (A), proteins (B) and the downregulated genes (C), proteins (D) during the training period (interferome database). Note there are very few datasets for type III interferons—only twenty datasets from just two human experiments; thus any interpretation of type III interferons should be done with caution (http://www.interferome.org/interferome/home.jspx).