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. 2022 Jan 10;13(1):32. doi: 10.1038/s41419-021-04345-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Representative images of xenograft tumors (five mice per group) in nude mice. B Tumor volume is monitored every 4 days for 28 days. C The weights of xenograft tumors are summarized. D, E Immunohistochemical verification of the expression of Ki67 in tumors tissues. **, ## P < 0.01. F, G qRT-PCR verification of the expression of hsa_circ_0004658 F and miR-499b-5p G in tumors (n = 5). **, ##P < 0.01, * vs. sh-control, # vs. RBPJ^+/+ Mφ-Exo. H The protein expression of JAM3 was detected by western blotting in tumors (n = 5).