Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 10;12:351. doi: 10.1038/s41598-021-04131-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Cell-based screening of αSyn aggregation inhibitors. (A) Quantification of the number of nuclei (white bars) and the percentage of cells containing obvious αSyn-EGFP inclusion bodies (black bars), standardized by those of cells treated with DMSO. Concentration of the drugs are indicated at the right. The numbers under the graph correspond to the numbers in Table 1. Data are shown as the mean ± SEM of three independent wells (n = 3; *P < 0.05; one-way ANOVA with the Dunnett test compared with the DMSO control). (B) Representative images of tannic acid-treated HeLa cells. Cells were transfected with pCMV αSyn-EGFP, followed by treatment with αSyn PFF and the indicated concentrations of tannic acid. (C) Quantification of the number of nuclei (white bars) and the percentage of cells containing obvious αSyn-EGFP inclusion bodies (black bars) in B standardized by those of cells treated with DMSO. Data are shown as the mean ± SEM of three independent wells (n = 3; *P < 0.001; one-way ANOVA with the Dunnett test compared with the no tannic acid control).