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. 2022 Jan 10;12:351. doi: 10.1038/s41598-021-04131-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tannic acid inhibits the formation of αSyn aggregates in mouse primary cultured neurons and PD model C. elegans. (A) Representative immunocytochemistry images of primary cultured neuronal cells treated with αSyn PFF and tannic acid. Primary neurons were treated with the indicated combinations at DIV 7, and were stained at DIV 14. (B) Quantification of pS129 αSyn in PFF- and tannic acid-treated neurons. Relative pS129 αSyn area per number of NeuN-positive neuronal cells was standardized by that of cells treated with αSyn PFF and DMSO. Data are shown as the mean ± SEM of three independent wells (n = 3; **P < 0.01; ***P < 0.001; one-way ANOVA with the Dunnett compared with the αSyn PFF without tannic acid control) (C) Representative images of the heads of PD model C. elegans treated with DMSO or tannic acid. (D) Quantification of the number of obvious puncta in C. elegans treated with tannic acid or the DMSO control. Data are shown as the mean ± SEM of twenty-eight worms (n = 28; ***P < 0.001; Student t-test).