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. 2022 Jan 10;12:351. doi: 10.1038/s41598-021-04131-9

Table 1.

Top 30 hit compounds identified in the ThT screening assay for αSyn fibrillation inhibitors.

Compound Mean lag time (min) n = 3
0.37 μM 1.1 μM 3.3 μM 10 μM
1 Tannic acid 1770 2015 2505 2505
2 Cisplatin 845 845 2370 2505
3 Apomorphine hydrochloride 1245 1980 2330 2505
4 Norepinephrine 1125 1530 2040 2505
5 Diflunisal 1730 1850 1965 2505
6 Rabeprazole sodium 985 1665 2015 2500
7 Althiazide 1120 1555 1780 2200
8 Dopamine hydrochloride 1065 1295 1620 2085
9 Hymechrome 1800 1705 1820 2070
10 Pantoprazole 950 1215 1785 2070
11 Tamoxifen citrate 1255 1305 1515 2070
12 Donepezil hydrochloride 1345 1340 1560 2030
13 Hyoscyamine 1405 1450 2195 2010
14 Glucosamine hydrochloride 1190 1760 2095 1925
15 Methyldopa 1440 1415 1240 1925
16 Chlorophyllide Cu complex Na salt 820 930 1000 1920
17 Isotretinoin 1495 1485 2050 1885
18 Pirenperone 1355 1450 1865 1845
19 Entacapone 1385 1695 1830 1800
20 Nisoldipine 1285 1450 1490 1795
21 Chloroxine 1345 1445 1875 1785
22 Paroxetine hydrochloride 1330 1385 1620 1705
23 Risedronate sodium 1260 1520 1640 1700
24 Nateglinide 955 1370 1360 1630
25 Diethylcarbamazine citrate 1060 1350 1470 1625
26 Deferoxamine mesylate 1260 1335 1255 1580
27 Fenoldopam mesylate 1120 1180 1390 1400
28 Oxidopamine hydrochloride 1045 1055 1125 1365
29 Oxyquinoline sulfate 575 725 815 1060
30 Neomycin sulfate 670 815 810 980