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. 2022 Jan 10;13:83. doi: 10.1038/s41467-021-27648-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Left and middle panels: Quantification of the indicated PI(3,4,5)P₃ and PI(3,4)P₂ acyl variants in prostate tissues from WT and prostate-specific Pten-deficient (PbCre4-Pten^flox/flox) mice at 12 weeks of age (n = 3 independent animals/group). The altered acyl chain profile in Pten-deficient cancerous tissues was confirmed in five independent experiments. Right panel: Total of the PI(3,4)P₂ and PI(3,4,5)P₃ acyl variants in the tissues in the left and middle panels. b Measurements of the indicated acyl variants and total PI, PI3P, PI4P, and PI(4,5)P₂ in the prostate tissues from the WT (blue) and PbCre4-Pten^flox/flox (red) mice in (a) (12 weeks of age, n = 3). For all panels, data were the mean ± SD (n = 3 independent animals). ND not determined. The significance between WT and PbCre4-Pten^flox/flox mice was analyzed using a two-sided Welch’s t-test. Source data are provided as a Source Data file.