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. 2022 Jan 10;13:115. doi: 10.1038/s41467-021-27726-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Superimposition of the structures of BDM88855 (9) (green compound) bound AcrB (pdb 7OUK) and MBX3132 (red compound) bound AcrB (pdb 5ENQ¹⁹), shows these efflux pump inhibitors to occupy different protomer states of AcrB (the blue T protomer for BDM88855 (9) and the yellow L protomer for MBX3132), in spatially distant binding pockets.