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. 2022 Jan 6;17:45–60. doi: 10.2147/IJN.S333496

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© 2022 Chen et al.

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Effect of dimercaptosuccinic acid (DMSA)-SPIONs on P. gingivalis LPS-induced inflammatory response in hGFs. (A) Superconducting quantum interference device (SQUID) magnetometer magnetic hysteresis loops of PSC-SPIONs at 300 K. (B) TEM images of PSC-SPIONs and DMSA-SPIONs. (C) Gene expression (mRNA levels) of IL-1β, TNF-α, IL-6, IL-8, and COX-2 in D-S-treated hGFs stimulated with P. gingivalis LPS. Histograms show means ± SD from three independent experiments. ^##P < 0.01 compared with hGF negative control; **P < 0.01 compared with hGF+LPS positive control.

Abbreviations: P-S, PSC-SPIONs; D-S, DMSA-SPIONs.