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. 2021 Dec;10(12):4333–4343. doi: 10.21037/tau-21-761

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2021 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The characteristic and pathways of macrophages involved in murine systemic lupus erythematosus nephritis. (A) Principal component analysis (PCA) plot of the separation between the group of samples taken in the early-stage lupus (the young mac group), the group of samples taken during lupus nephritis (the sick mac group) and the group of samples taken after induction of remission (the rem mac group); (B) volcano plot of differentially expressed genes (DEGs) between the young mac group and sick mac group and between the sick mac group and rem group (P<0.05 and |log_FC| >1); (C) the enriched biological process terms of the DEGs as identified via Gene Ontology (GO) functional annotation; (D) the enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway terms of the DEGs; (E) gene set enrichment analysis (GSEA) was performed to identify significantly enriched pathways.