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. 2021 Dec;10(12):4333–4343. doi: 10.21037/tau-21-761

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2021 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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The characteristic and pathways of macrophages involved in murine renal ischemia-reperfusion injury (IRI). (A) Principal component analysis (PCA) plot of the separation between the sham surgery (sham) group, the group of samples taken 4 h postperfusion after IRI (the 4 h group), the group of samples taken 24 h postperfusion after IRI (the 1-day group) and the group of samples taken 9 days postperfusion after IRI (the 9-day group); (B) volcano plot of the differentially expressed genes (DEGs) between the 1-day group and sham group (P<0.05 and |log_FC| >1); (C) the enriched biological process terms of the DEGs as identified via Gene Ontology (GO) functional annotation; (D) the enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway terms of the DEGs; (E) gene set enrichment analysis (GSEA) was performed to identify significantly enriched pathways; (F) the Venn diagram represents common and unique pathways that were significantly altered in different datasets.