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Schematic illustration of ASB17 during spermiation. At the beginning of spermiation, ESPN is degraded through the ASB17-mediated ubiquitin proteasome system (UPS), thereby leading to apical ES disassembly and mature spermatozoa disengagement. The absence of ASB17 stabilizes ESPN and finally causes spermiation failure. ASB17, ankyrin repeat and SOCS box protein 17.
