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. 2021 Dec 4;298(1):101460. doi: 10.1016/j.jbc.2021.101460

Figure 7.

Figure 7

Features of the Y-model.A, MD frame of the Y-model highlighting three features of interest. B, the amide group of FtsB Gln-39 and the guanidinium group of FtsL Arg-67 and Arg-74 are partially solvent exposed, whereas only the shorter FtsB Asn-43 is mainly buried. The polar cluster side chains tend to interact with each other in a shared network of hydrogen bonds. C, a patch of Ala residues on the opposite face of the FtsL/FtsB coiled-coil interfaces mediates the interaction of the two FtsB helices. The interaction is stable through the entire replica MD runs. D, the FtsB Gly-rich linker forms a short loop of four amino acids. The helical termini of the transmembrane and coiled-coil helices remain in contact in a configuration that resembles a continuous helix. There is hydrogen bond formation between the carbonyl groups of transmembrane residues 19 to 20 and the N–H groups of residues 26 to 27 of the coiled coil. MD, molecular dynamics.