Table 4. Multivariable cox regression analyses of survival in male thyroid cancer.
Characteristics | Variable | Cancer-specific survival | Overall survival | |||
---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |||
Tumor size | ≤1 cm | 1 | – | 1 | – | |
>1 cm | 3.354 (2.457–4.579) | <0.001 | 0.984 (0.864–1.120) | 0.802 | ||
Race | Black | 1 | – | 1 | – | |
White | 0.947 (0.596–1.505) | 0.819 | 0.776 (0.630–0.955) | 0.016 | ||
Other | 0.933 (0.535–1.626) | 0.807 | 0.742 (0.572–0.963) | 0.025 | ||
Age, years | <55 | 1 | – | 1 | – | |
≥55 | 4.003 (3.161–5.070) | <0.001 | 4.499 (3.967–5.102) | <0.001 | ||
Median income | <$55,000 | 1 | – | 1 | – | |
≥$55,000 | 0.635 (0.493–0.816) | <0.001 | 0.785 (0.687–0.897) | <0.001 | ||
Surgery performed | No | 1 | – | 1 | – | |
Yes | 0.063 (0.045–0.088) | <0.001 | 0.192 (0.152–0.242) | <0.001 | ||
histology recode/pathological type | Medullary | 1 | – | 1 | – | |
HCC | 0.539 (0.348–0.836) | 0.006 | 1.017 (0.737–1.403) | 0.918 | ||
Follicular | 0.247 (0.159–0.385) | <0.001 | 0.814 (0.606–1.094) | 0.173 | ||
Pap with Fv | 0.107 (0.073–0.157) | <0.001 | 0.719 (0.558–0.928) | 0.011 | ||
Papillary | 0.171 (0.126–0.231) | <0.001 | 0.750 (0.592–0.951) | 0.028 | ||
T stage | Tx | 1.912 (0.782–4.677) | 0.156 | 0.677 (0.314–1.463) | 0.321 | |
T0 | 0.479 (0.177–1.296) | 0.147 | 0.783 (0.462–1.326) | 0.363 | ||
T1 | 0.036 (0.027–0.050) | <0.001 | 0.391 (0.316–0.484) | <0.001 | ||
T2 | 0.068 (0.048–0.095) | <0.001 | 0.441 (0.351–0.554) | <0.001 | ||
T3 | 0.154 (0.121–0.196) | <0.001 | 0.498 (0.413–0.601) | <0.001 | ||
T4 | 1 | – | 1 | – | ||
N stage | Nx | 0.642 (0.414–0.996) | 0.048 | 1.214 (0.864–1.707) | 0.263 | |
N0 | 0.258 (0.225–0.296) | <0.001 | 0.965 (0.822–1.133) | 0.664 | ||
N1 | 1 | – | 1 | – | ||
M stage | Mx | 0.044 (0.024–0.081) | <0.001 | 0.432 (0.260–0.718) | 0.001 | |
M0 | 0.024 (0.020–0.028) | <0.001 | 0.364 (0.291–0.457) | <0.001 | ||
M1 | 1 | – | 1 | – | ||
Combined summary stage | Localized | 1 | – | 1 | – | |
Regional | 3.688 (3.084–4.411) | <0.001 | 1.135 (0.998–1.291) | 0.054 | ||
Distant | 56.280 (47.287–66.984) | <0.001 | 2.153 (1.639–2.829) | <0.001 |
HCC, Hurthle cell carcinoma; Pap with Fv, papillary with follicular variant.