Table 2.
Neurocognitive measures between depressed patients with and without evidence of inflammation.
|
Measures |
Patients without Evidence of Inflammation (n = 43) (CRP<3 mg/L) Mean (SD) |
Patients wit Evidence of Inflammation (n = 37) (CRP ≥3 mg/L) Mean (SD) |
Mean Difference (95% CI)1 |
|||||
|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted for age, sex and BMI | Adjusted for age, sex BMI, and depression | Adjusted for age, sex BMI, and fatigue | Adjusted for age, sex, BMI, depression and fatigue | Test Statistic and p value for final model | |||
| CANTAB EBT Bias Point | 6.96 (1.44) | 7.20 (1.31) | -0.23 (-0.86 – 0.39) | 0.13 (-0.75 – 0.77) | 0.07 (-0.76 – 0.91) | -0.01 (-0.85 – 0.81) | 0.03 (-0.82 – 090) | F = 0.008, p = 0.92 |
| CANTAB EBT Median Reaction Time Sad Faces (miliseconds) | 671.80 (163.57) | 729.77 (180.41) | -57.96 (-135.64 – 19.70) | -51.05 (-150.04 - 47.94) | -16.26 (-123.26 – 90.74) | -37.36 (-144.822 – 70.10) | -16.21 (-126.78 – 94.35) | F = 0.086, p = 0.77 |
| CANTAB EBT Median Reaction Time Happy Faces (miliseconds) | 701.82 (157.44) | 737.84 (253.02) | -36.01 (-129.31 – 57.28) | -21.00 (-140.89 – 98.88) | 65.03 (-56.82 – 186.90) | 13.89 (-114.84 – 142.63) | 65.85 (-60.07 – 191.77) | F = 1.088, p = 0.30 |
| ECAT Total Recalled Correct (Positive Words) | 3.33 (1.87) | 2.76 (1.65) | 0.08 (-0.02 – 0.19) | 0.06 (-0.06 – 0.20) | 0.07 (-0.07 – 0.21) | 0.10 (-0.03 – 0.24) | 0.09 (-0.05 – 0.23) | F = 1.534, p = 0.54 |
| ECAT Total Recalled Correct (Negative Words) | 2.09 (1.55) | 2.22 (1.68) | 0.06 (-0.05 – 0.18) | 0.06 (-0.08 – 0.21) | -0.017 (-0.13 – 0.17) | -0.024 (-0.17 – 0.12) | -0.018 (-0.17 – 0.13) | F = 0.050, p = 0.82 |
| ECAT Accuracy | 34.17 (7.89) | 34.96 (6.79) | -0.03 (-0.13 – 0.07) | -0.04 (-0.16 – 0.07) | -0.025 (-0.15 – 0.10) | -0.04 (-0.16 – 0.08) | -0.027 (-0.16 – 0.10) | F = 0.160, p = 0.68 |
| ECAT Reaction Time - Positive Words (miliseconds) | 998.01 (289.42) | 877.08 (346.59) | 0.06 (-0.01 – 0.13) | 0.05 (-0.028 – 0.14) | 0.071 (-0.021 – 0.16) | 0.081 (-0.007 – 0.16) | 0.082 (-0.01 – 0.17) | F = 3.115, p = 0.08 |
| ECAT Reaction Time - Negative Words (miliseconds) | 10007.58 (309.28) | 902.34 (300.33) | 0.36 (-0.03 – 0.10) | 0.03 (-0.05 – 0.11) | 0.05 (-0.03 – 0.13) | 0.061 (-0.020 – 0.142) | 0.061 (-0.024 – 0.146) | F = 2.028, p = 0.15 |
| Digit symbol coding score | 70.21 (15.76) | 62.14 (17.55) | ∗0.06 (0.003–0.11) | 0.036 (-0.030 – 0.10) | 0.016 (-0.055 – 0.087) | 0.025 (-0.04 – 0.09) | 0.014 (-0.059 – 0.087) | F = 0.147, p = 0.70 |
| RTI Median Simple Movement Time (miliseconds) | 216.47 (46.82) | 243.04 (53.64) | ∗-26.56 (-48.92 - -4.20) | -24.74 (-52.47 – 2.97) | -25.52 (-55.82 – 4.76) | -22.61 (-52.48 – 7.25) | -23.96 (-55.04 – 7.12) | F = 2.361, p = 0.12 |
| RTI Median Simple Reaction Time (miliseconds) | 316.58 (40.77) | 320.10 (34.32) | -3.52 (-20.46 - -13.40) | 3.59 (-17.25 – 24.45) | 11.46 (-10.83 – 33.75) | 10.61 (-11.40 – 32.64) | 13.95 (-8.77 – 36.68) | F = 1.498, p = 0.22 |
| RTI Median Five-Choice Movement Time (miliseconds) | 260.86 (60.21) | 281.05 (69.27) | -20.19 (-49.01 – 8.62) | -2.93 (-36.99 – 31.12) | -1.98 (-39.20 - 35.24) | 1.34 (-35.28 – 37.97) | 0.52 (-37.62 – 38.66) | F = 0.001, p = 0.97 |
| RTI Median Five-Choice Reaction Time (miliseconds) | 354.98 (37.44) | 375.01 (59.10) | -20.02 (-41.74 – 1.69) | -17.26 (-44.63 – 10.09) | -8.73 (-38.19 – 20.73) | -6.0 (-35.17 – 22.16) | -4.00 (-33.77 – 25.76) | F = 0.072, p = 0.78 |
| RVP A’ (Signal Detection) | 0.90 (0.05) | 0.89 (0.05) | 0.007 (-0.01 – 0.03) | 0.009 (-0.02 – 0.03) | 0.014 (-0.01 – 0.04) | 0.016 (-0.01 – 0.04) | 0.017 (-0.015 – 0.04) | F = 1.152, p = 0.28 |
| RVP Median Response Latency (miliseconds) | 454.66 (82.03) | 448.05 (81.06) | 6.60 (-29.81 – 43.03) | 37.43 (-4.47 – 79.35) | ∗47.99 (2.62–93.35) | ∗48.05 (3.37–92.72) | ∗52.10 (5.72–98.48) | F = 5.015, p = 0.02 |
| RVP Probability of False Alarm | 0.017 (0.05) | 0.015 (0.03) | 0.002 (-0.01 – 0.02) | 0.009 (-0.01 – 0.03) | 0.001 (-0.026 – 0.029) | 0.002 (-0.026 – 0.029) | -0.001 (-0.03 – 0.02) | F = 0.009, p = 0.92 |
| CANTAB OTS Problems Solved on First Choice | 11.00 (2.23) | 10.97 (2.65) | -0.15 (-1.26 – 0.96) | 0.07 (-1.32 – 1.48) | 0.41 (-1.12 – 1.95) | -0.08 (-1.59 – 1.43) | -0.006 (-1.59 – 1.58) | F < 0.001, p = 0.99 |
| CANTAB OTS Median Latency to First Choice (miliseconds) | 10517.55 (3708.81) | 9750.94 (4190.28) | 0.04 (-0.03 – 0.12) | 0.06 (-0.02 – 0.15) | 0.088 (-0.008 – 0.18) | 0.078 (0.01–0.17) | 0.09 (-0.01 – 0.19) | F = 3.190, p = 0.07 |
| CANTAB PAL Total Errors Adjusted | 10.79 (10.28) | 12.30 (12.75) | 0.07 (-0.10 – 0.25) | 0.006 (-0.20 – 0.21) | -0.08 (-0.31 – 0.14) | -0.07 (-0.30 – 0.15) | -0.10 (-0.33 – 0.13) | F = 0.712, p = 0.40 |
| CANTAB PAL First Attempt Memory Score | 14.00 (3.97) | 13.19 (3.28) | -0.10 (-0.07 – 0.05) | 0.01 (-0.06. – 0.08) | 0.06 (-0.02 – 0.15) | 0.07 (-0.01 – 0.15) | 0.07 (-0.008 – 0.16) | F = 3.263, p = 0.07 |
Asteriks denote significance level at p < 0.05.