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. 2021 Dec 9;7(2):100867. doi: 10.1016/j.adro.2021.100867

Figure 6.

Fig 6

ECM changes following SCRT. (A) Representative images of untreated (UT; left) and irradiated (SCRT; right) tumors on day 14 with trichrome stain. Tumor margins annotated (bottom; black outline). Collagen pixels in the tumor were determined using an algorithm in ImageScope software (bottom). (B, C) Quantification of fibrosis per area of tumor on days 14 and 18. Significance determined by unpaired t test. (D) Representative images of HA stain on day 14 with positive HA pixels determined by ImageScope. Significance determined by unpaired t test. (E, F). Quantification of HA on days 14 and 18. Significance determined by unpaired t test. Abbreviations: D = day; ECM = extracellular matrix; HA = hyaluronic acid; SCRT = short course radiation therapy; UT = untreated.