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. 2021 Dec 25;25(1):103679. doi: 10.1016/j.isci.2021.103679

Figure 4.

Figure 4

Genome-wide transcriptional regulation by SETBP1 and SETBP1(D/N) in mouse LSK cells

(A) Upper panels, mapping of top 5,000 peaks (by q-value) from SETBP1 and SETBP1(D/N) ChIP-seq data. Lower panels, Venn diagrams showing overlaps of SETBP1-bound or SETBP1(D/N)-bound peaks in indicated genomic regions. p Values for overlaps were calculated by hypergeometric test.

(B) Pie charts showing the numbers of differentially expressed genes induced by Setbp1 and Setbp1(D/N) expression in mouse LSK cells.

(C) Top GO gene sets with positive enrichment from GSEA analysis of differentially expressed genes in mouse LSK cells induced by ectopic Setbp1 and Setbp1(D/N) expression.

(D) GSEA analysis of differentially expressed genes in mouse LSK cells induced by Setbp1 expression using indicated gene sets.

(E) Genome browser tracks representing SETBP1 and SETBP1(D/N) shared occupancy at indicated loci of oncogenic transcription factor genes and ribosomal protein genes.