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. 2021 Dec 25;25(1):103679. doi: 10.1016/j.isci.2021.103679

Figure 5.

Figure 5

Co-localization of SETBP1 and SETBP1(D/N) with MLL1 at oncogenic transcription factor genes and ribosome protein genes

(A) Mapping of MLL1-N ChIP-seq peaks in mouse LSK cells overexpressing Setbp1 or Setbp1(D/N).

(B) Venn diagrams showing overlaps of top 5,000 SETBP1-bound or SETBP1(D/N)-bound peaks with top 5,000 MLL1-bound peaks in LSK cells overexpressing Setbp1 or Setbp1(D/N). p Values were calculated using hypergeometric test.

(C) Average binding profiles of H3K4me3 at promoter regions of SETBP1-bound, MLL1-bound, and SETBP1/MLL1 co-bound targets.

(D) Genome browser tracks showing co-localization of SETBP1, MLL1, H3K4me3, and H4K16ac at indicated loci of oncogenic transcription factor gene targets and ribosomal protein gene targets.

(E) Genome browser tracks showing co-localization of SETBP1(D/N), MLL1, H3K4me3, and H4K16ac at the same target loci as in (D).