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. 2020 Feb 24;4(1):e100013. doi: 10.1136/bmjos-2019-100013

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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The impact of comorbidity and intervention type on reduction in infarct volume. The degree of protection observed in aged or comorbid animals varied depending on the type of comorbidity modelled (A; p=0.017) and the type of intervention administered (B; p<0.001). Results are presented as the mean±95% CIs, n=163 outcomes in total. The number of outcomes in each subgroup is shown in brackets. The horizontal grey bars represent the 95% CIs of the combined effect of the comorbid data. HMG-CoA, hydroxymethylglutaryl-coenzyme A; NO, nitric oxide; NOS, nitric oxide synthase; PPAR, peroxisome proliferator-activated receptor.