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Return on investment (ROI) sensitivity analysis: variation of number of subjects, sites, and counterfactual studies used to calculate ROI
| Parameters | Variations | Compared with ROI 555% |
| Subjects | Plus 10% | 603 |
| Plus 5% | 579 | |
| Minus 5% | 531 | |
| Minus 10% | 507 | |
| Study sites | Plus 10% | 559 |
| Plus 5% | 557 | |
| Minus 5% | 553 | |
| Minus 10% | 551 | |
| Counterfactual cases | >counterfactual studies 22, maximum, no combined studies | 682 |
| <counterfactual studies than 10, combining 12 studies | 368 |
