Odds of complicated course by time 1 (T1) biomarkers, stratified by acute respiratory distress syndrome (ARDS) status. Data are presented as adjusted odds ratio (OR) with 95% CIs for the association of T1 biomarkers with complicated course, stratified by ARDS status. A p value of less than or equal to 0.10 was defined a priori to indicate a significant difference in the odds of complicated course in sepsis patients with versus without ARDS. Ang = angiopoietin, CRP = C-reactive protein, ICAM = intracellular adhesion molecule, IL = interleukin, sFLT = soluble fms-like tyrosine kinase, Tie-2 = tyrosine kinase with immunoglobulin-like loop epidermal growth factor homology domain 2, VCAM = vascular adhesion molecule, VEGF = vascular endothelial growth factor, vWF = von Willebrand factor.