Table 4. Multivariate Cox regression analysis on the risk factors associated with mortality in patients with COVID-19.

Variables	HR (95% CI)	P value
Age, y	1.02 (1-1.04)	0.038
Heart failure	2.03 (1.14-3.60)	0.016
Cancer/autoimmune disease	5.57 (2.08-14.92)	0.001
Arrhythmia	2.02 (1.10-3.72)	0.024
Severity	5.36 (2.37-12.15)	0.000
Interferon beta 1-a	1.76 (1.02-3.03)	0.043

We used a univariate Cox regression analysis to assess possible factors associated with higher mortality. Age, history of heart failure, history of cancer/autoimmune disease, acute respiratory distress syndrome, arrhythmia, in-hospital treatment with inotropic, atazanavir, heparin, and interferon beta 1-a, antibiotic therapy, and severity were significant factors with a P-value < 0.1 that further entered in the multivariate analysis.