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. 2022 Jan 11;13(1):e02785-21. doi: 10.1128/mbio.02785-21

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Copyright © 2022 Lin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Dose-dependent vaccination effect of heat-killed H99 and ZNF2^oe cells. (A) Schematic representation of the vaccination regimens using live or heat-killed ZNF2^oe cells. The lung fungal burdens at DPI 12 of the (5 mice) control mice without vaccination and of mice vaccinated with (10 mice) live or (10 mice) heat-killed ZNF2^oe cells at the indicated doses are shown. (B) Schematic representation of the vaccination regimen using heat-killed H99 cells at two different doses. The lung fungal burdens at DPI 14 of the 5 mice vaccinated with heat-killed H99 cells at the typical dose of 1 × 10⁷ cells/animal or the higher dose of 5 × 10⁷ cells/animal are shown. (C) Schematic representation of the vaccination regimen using heat-killed H99 cells and heat-killed ZNF2^oe cells. The lung fungal burden at DPI 14 of the 5 mice vaccinated with these heat-killed cells at the higher dose of 5 × 10⁷ cells/animal are shown. The group without vaccination was included as the control.