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. 2022 Jan 11;13(1):e02785-21. doi: 10.1128/mbio.02785-21

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Copyright © 2022 Lin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — Brf1 is critical for the protective effect elicited by ZNF2 overexpression. (A) Phenotypical analyses of H99, ZNF2^oe, brf1Δ, and ZNF2^oebrf1Δ on thermo- or CO₂- tolerance (YPD at 30°C, 30°C + 10% CO₂, and 37°C) and melanization (L-Dopa medium at 22°C). (B) The lung fungal burden at day 12 postinoculation with live H99 (5 mice), ZNF2^oe (5 mice), brf1Δ (5 mice), or ZNF2^oebrf1Δ (5 mice) at the inoculum of 1 × 10⁴ cells/animal. (C) Animal survival was monitored for 60 days after inoculation with live H99 (10 mice) or ZNF2^oebrf1Δ (10 mice) at 1 × 10⁴ cells/animal. The survival rate was plotted against the days postinoculation. (D) The lung fungal burden of the surviving mice inoculated with live ZNF2^oebrf1Δ (10 mice) at the time of termination (DPI 60) compared the lung fungal burden of mice infected with live H99 (10 mice) at time of euthanization when they reached defined clinical endpoints. (E) Survival of mice vaccinated with live ZNF2^oebrf1Δ (10 mice) or ZNF2^oe (10 mice) after challenge with live H99. (F) Survival of mice vaccinated with heat-killed ZNF2^oebrf1Δ (10 mice) or ZNF2^oe (10 mice) after challenge with live H99.