Table 2.

Resting-state functional connectivity associated with fatigue in people with traumatic brain injury (TBI) and healthy controls (HC). (Upper panel) regions with a significant association between task-induced fatigue and changes in rsFC (post – pre-task) over all participants and (lower panel) regions where the associations were significantly different in people with TBI compared to HC.

		Size (voxels)	Coordinates			F-stats (df) model
All subjects	L/R		x	y	z	T(2, 29)	p-voxel	p-cluster
Medial prefrontal cortex
Insular cortex	L	58	–32	20	−2	6.19	0.000000	0.002847
Frontal pole	R	42	22	48	−14	5.04	0.000056	0.008855
Posterior cingulate cortex
Lateral occipital cortex inferior division	L	127	−52	−72	−10	5.92	0.000018	0.000053
Supramarginal gyrus anterior division	L	87	−64	−28	30	4.52	0.000052	0.000473
Parahippocampal gyrus anterior division hippocampus	R	84	22	−10	−24	−8.40	0.000001	0.000565
Hippocampus Amygdala	L	57	–22	−10	−16	−6.25	0.000002	0.003103
Superior frontal gyrus	L	55	−24	2	70	4.67	0.000199	0.003554
Differences TBI vs HC									changes rsFC (post – pre)		T-stats (df) per group
			x	y	z	F(1,27)	p-voxel	p-cluster	TBI	HC	TBI	HC
Striatum
Precuneus cortex		66	−8	−70	+54	27.14	0.000011	0.000589	0.07	−0.07	t(12) = 3.30, p = .006	t(13) = − 3.99, p = .0015
Cerebellum 4,5	L	36	−4	−58	−18	37.46	0.000058	0.009234	0.04	0.02	t(12) = −7.61, p = .000006	t(13) = 1.68, p = .12
T(2,29) threshold > 3.66; F(1,27) threshold > 13.61; uncorrected voxel threshold p < .001; uncorrected cluster threshold p < .0167 (Bonferroni corrected). Analyses were controlled for age and sex. rsFC, resting-state functional connectivity (fisher-z transformed correlation coefficients).