Figure EV5. Treatment with an OGT inhibitor improves severe loss of body weight due to the hemorrhagic symptoms in the intestines of mice challenged with Stx2a.

1. Body weight changes in mice challenged with Stx2a in the presence or absence of OSMI‐1 (300 or 1,000 µg/mouse). Data are presented as mean ± SD (n = 5 biological replicates per group, two‐tailed Student’s t‐test). Comparisons between days 0 and 3 were indicated for each group. *P < 0.05; **P < 0.01; and ***P < 0.001.
2. Representative images of the intestines of mice at day 3 after Stx2a injection and combinatorial treatment with two doses of OSMI‐1 or the vehicle alone.

Source data are available online for this figure.