Table 3.

Multiplex electrochemical aptasensors based on enzymatic tags.

Analytes	Method	LOD/Range	Signal Tags	Ref.
PDGF, thrombin	DPV	PDGF: 8 pM/0.01–35 nM Thrombin: 11pM/0.02–45 nM	bienzyme: glucose oxidase, HRP, Tb, Fc	[91]
AML, ALL	DPV	~350 cells per mL/5 × 102–1 × 107 cells per mL	HRP, Aq, Thi	[92]

ALL, acute lymphocytic leukemia cells; AML, acute myeloid leukemia cells; Aq, anthraquinone; DPV, differential pulse voltammetry; Fc, ferrocene; HRP, horseradish peroxidase; PDGF, platelet-derived growth factor; Tb, toluidine blue; and Thi, thionine.